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NeuroMethylation Cream
120 Servings | 1.8 oz
by NuMedica

NuMedica NeuroMethylation Cream (Enhanced Formula) - 1.8 oz professional-grade dietary supplement NuMedica NeuroMethylation Cream (Enhanced Formula) - 1.8 oz professional-grade dietary supplement

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NeuroMethylation Cream - 1.8 oz | 120 Servings   

NeuroMethylation Cream - 1.8 oz | 120 Servings
NuMedica NeuroMethylation Cream (Enhanced Formula) - 1.8 oz professional-grade dietary supplement

NuMedica NeuroMethylation Cream

Options: 120 Servings | 1.8 oz
Weight: 3.1 oz
UPC: 812527013032   
SKU: NM303   

Foundation Neuro-Immune Support Formula*

Topical cream that provides the nutrients essential for optimal neurological and immune system function.*

SKU: NM303   UPC: 812527013032   Weight: 3.1 oz
Gluten Free  Quatrefolic  Popular  
NeuroMethylation Cream - 1.8 oz | 120 Servings   

NeuroMethylation Cream - 1.8 oz | 120 Servings
NuMedica NeuroMethylation Cream (Enhanced Formula) - 1.8 oz professional-grade dietary supplement
  • product reviews icon  Product Reviews*: 6

    Product Reviews*

    Reviews are from verified customers who purchased the product on They are intended to describe the quality and usefulness of the specific product i.e. "how is the product working for you?". Any benefits or results expressed are based on individual experiences that are unique, cannot be guaranteed, and have not been evaluated by the FDA. Consult with your healthcare practitioner to determine if any supplement you are considering purchasing would be a good option for your specific needs.

    Seems great

    rating star iconrating star iconrating star iconrating star iconrating star icon on January 31, 2021
    - Verified Purchase
    I've been taking it. It lasts a long time. It has no adverse affects.
    rating star iconrating star iconrating star iconrating star iconrating star icon on October 22, 2020
    - Verified Purchase
    This product works very well I use it every morning and it gives me a boost. Helps mental focus and gives energy
    rating star iconrating star iconrating star iconrating star iconrating star icon on September 24, 2020
    - Verified Purchase
    I've been using this cream for some time. My functional medicine doctor recommends I continue to use it since I have methylation issues. It's pricey but a little goes a long ways.
    rating star iconrating star iconrating star iconrating star iconrating star icon on September 24, 2020
    - Verified Purchase
    I can tell when I've been off this cream for too long. Pain/tingling in my feet, muscle aches in my legs, periodic heart rhythm irregularities. The feet and leg issues go away and the heart rhythm issues become rare after 4-5 days back on the cream.

    Cognitive improvement observed

    rating star iconrating star iconrating star iconrating star iconrating star icon on September 16, 2020
    - Verified Purchase
    Our young adult son has impaired B12 pathway and has been using this supplement for several years. We notice stronger cognitive performance when he regularly applies it, and weaker cognition when he doesn't.


    rating star iconrating star iconrating star iconrating star iconrating star icon on October 14, 2019
    - Verified Purchase
    Felt the calming effect immediately.
  • Description*

    Optimal Neurological and Immune System Function from NuMedica NeuroMethylation Cream

    NuMedica NeuroMethylation Cream is available as a topical cream to provide you with the essential nutrients that support the body's methylation processes. Methylation is among the body's most common and most important chemical processes. It occurs in essential chemical reactions such as folate metabolism and cardiovascular health, detoxification and hormonal regulation. While a healthy lifestyle can promote adequate methylation, common exposure to environmental pollutants, stress and toxins prevent most people from having enough methyl groups. NuMedica NeuroMethylation Cream supports immune health and normal neurotransmitter production and metabolism.

    About NeuroMethylation Cream

    NuMedica NeuroMethylation Cream is formulated with five essential nutrients that support the body's methylation processes, including the "L" form of 5-MTHF, Vitamin B-12 as hydroxycobalamin, Vitamin B-12 as methylcobalamin, Vitamin B-6 and Vitamin D-3. This advanced formula, which is the foundation formula in NuMedica's Advanced Neuro-Immune Program, supports immune health and normal neurotransmitter production and metabolism. Insufficient methyl groups are associated with symptoms such as obesity, depression, mood disorders, tinnitus, chronic fatigue and more. NuMedica NeuroMethylation Cream ensures that the body's methylation processes have the support necessary for optimal function.

    Benefits of NeuroMethylation Cream

    NuMedica NeuroMethylation Cream promotes and improves the methylation processes that are needed to increase Vitamin D levels and provide optimal B-12, B-6 and vitamin delivery to the body's nervous and immune systems. It contains 5-MTHF, which is the metabolically active form of folic acid. Nearly a third of the population is deficient in the enzymes necessary to digest the folic acid found in foods and convert it to 5-MTHF. NuMedica NeuroMethylation Cream provides the 5-MTHF necessary for optimal health. This potent cream also helps improve mood stability, cognitive function, hormonal regulation, sleep/wake cycles and immune function. It includes nutrients such as Vitamin B-12 in methylated form and Vitamin D-3 to enhance the body's neurological and physical performance.

    Because this enhanced formula is applied directly to the skin, it effectively bypasses any mal-absorption issues that may occur in the gastrointestinal tract. These occurrences are especially prevalent when the body has high levels of toxins or digestive problems.

    NuMedica NeuroMethylation Cream provides the nutrients necessary to combat the issues commonly associated with insufficient methyl groups.

  • Directions

    Maintenance Dosage: 2 pumps daily; 1 pump in the morning and 1 pump in the evening.

    Advanced Dosage: 3 pumps daily; 1 pump in the morning, 1 pump mid-afternoon, 1 pump in the evening.

    For children under the age of 3 please consult with your healthcare practitioner.

  • Ingredients
    Nutrient/Ingredient Amount % Daily ValueDV 1
    5-MTHF (5-methyltetrahydrofolate), hydroxocobalamin, methylcobalamin, pyridoxal-5'-phosphate, natural vitamin D3

    5-MTHF plays an essential role in methylation, it enables the conversion of homocysteine to methionine, the production of serotonin and melatonin, and it is indirectly involved in the synthesis of DNA.


    Active Ingredients:

    1 The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advise.
  • Related Content*
    blog post author icon Additional Resources

    We encourage you to take advantage of these related Wellness Resources on our website.

    Supplements for Fatigue, Brain Fog, Memory, Sleep, ADHD & Behavioral Issues?

    Many people suffer from Neuro-Endocrine-Immune diseases and disorders. This is a very deep and very specific group of issues, and this article will only scratch the surface of what these products can do. I encourage you to dig deeper into product descriptions if something piques your interest.

About Quality, Reliable, Fast

Since 2010 has provided professional-grade supplements supported by practical wellness content focussed on healthy living, risk reduction, and chronic disease elimination.

jay, customer service representative, First Fitness Nutrition, NuMedica reseller
Customer Service: Jay promotes a lifestyle of well-being with emphasis on whole-foods nutrition, reasonable exercise, stress management, proper sleep, and the use of targeted, high-quality supplements to augment what is missing in our diet. We encourage others to live better through making small, gradual, healthy changes to lifestyle behaviors.

Jay is a founder of and has provided customer service, managed and operated the business ever since.

We welcome your  phone icon  call at (888) 424-0032 or  email icon  email anytime. We can't always respond immediately, but we will do so soon. We are even known to respond after hours and on weekends! Learn more about us.

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Order Policy

Please email if you have questions or need assistance.

Payment Processing

We accept Visa, MasterCard, Discover and American Express credit cards.

Payments are securely processed through industry leader of which is a Verified Merchant.

We DO NOT retain or store your credit card information after the purchase. We DO NOT share your information with anyone. We DO NOT auto-subscribe you to anything. Your information is YOURS.

The charge will appear on your credit card statement as with our phone number (888) 424-0032.

Shipping & Handling

A safe and accurate address for delivery must be provided at the time the order is placed. Once an order has shipped, is NOT responsible for lost or stolen packages CONFIRMED BY THE CARRIER to be delivered to the address provided for the order.

Since COVID-19, and the ensuing economic challenges in the USA economy, we respectfully ask that you allow some additional time for delivery for the carriers (USPS, UPS, and FedEx). Most orders still arrive on time, or near on time, but some may run late. We make every effort to get your order packed and into the carriers hands the same day, or by the next business morning if your order came in later in the previous day after carrier pickup, but we have no control over any delays that may happen within the shipping carrier's delivery system. Please order earlier for the time being if you are time-sensitive.

Orders that contain only FirstFitness Nutrition products have a shipping fee automatically calculated based upon the actual shipping weight of the items purchased. The charge ranges from $4.95 to $14.95.

For orders with NuMedica products you may choose from the shipping options below on the Order Checkout form in the Shipping Information section on the first line that says Choose Shipping Method.

Shipping Options

Country Option Schedule Cost
United States Standard 3-6 Days $4.95
United States Priority 2-4 Days $9.95
United States Free 7-10 Days $0.00
International FedEx International 4-7 Days $79.95*
International GlobalPost International 12-21 Days $39.95*
*International shipping costs may be higher depending upon package weight and destination. We will contact you for your approval of the additional amount if this occurs. may use the email or phone number provided on your Order to call or text you regarding Order Status or to inform you of changes to the Order Policy.

When your order ships we will send you a confirmation email with the delivery tracking information.

International Shipping

Shipping anything these days internationally is expensive. COVID resulted in more rigorous customs import processes, and now with much higher energy prices, international shipping rates are higher.

FedEx is the most reliable and faster carrier, at least for now, but they are expensive. Our FedEx international shipping fee is a minimum of $79.95. It usually makes more sense to get several months of supply (3 months or more) in one order to minimize the shipping expense per order over time. While the added weight of additional items may increase the base shipping price by a little (usually 10-25% depending upon total weight and destination), it is usually not by very much relative to shipping an additional small order later.

We also offer a lower-cost international shipping option using GlobalPost International for $39.95. So far, they have been reliable in getting packages correctly delivered but it takes 2 - 4 times as long to get the package delivered. Packages may take longer to process in the receiving country's customs process and status updates may not be reported as quickly. Please be patient if you choose this option to save money.

Some International orders may cost more to ship depending upon weight and location. If that happens we will contact you first and get your approval for any additional charge before proceeding. International orders may also be subject to additional customs fees and duties/taxes based upon the destination country's customs import laws and policies. These fees are NOT known or included on our order form and are typically charged and collected by the shipping carrier when they are delivering the product to it's final destination once the package has cleared the destination country's customs process. It is recommended that the buyer research custom import fees for the products/services they are importing beforehand to be aware of potential, additional fees.

Shipping Refrigerated Products

Our manufacturers formulate their probiotics to ensure their products retain viability until they reach the consumer. Probiotics that are recommended to be refrigerated remain so until the time of shipment, then shipped alongside an ice pack to ensure potency (Note: Ice pack will not arrive frozen, and product may not arrive cold). Orders placed on a Thursday-Sunday requiring cold shipping will not ship until the following Monday.


If your order has not been shipped yet, you can request a cancellation. Your original purchase amount will be refunded within three business days. If your order has already shipped, see Returns and Refunds.

Changes, Returns and Refunds

If you want to make a change to your order, please email us as soon as possible so we can make the change before your order ships. If your order has already shipped you may incur additional shipping charges for the second shipment and the return label for any products returned.

If we have made a mistake on your order, or the product arrives in a damaged or unusable condition, we will make every reasonable effort to right the situation quickly to your satisfaction. Problems of this nature must be reported to us within 5 business days of the package delivery date documented by the carrier status.

We accept returns subject to when the return is requested and the condition the product is returned in. All returns must first be authorized by contacting us. In your request, please let us know why you are returning the item(s). We will respond promptly with authorization, the return address, and a return shipping label if appropriate.

If your order has already shipped you can return any un-opened products within 30 days of receiving your order for a 100% refund of the price paid for the product, less the actual shipping charges we incurred to get the product to you originally and then returned, less a $10 restocking fee. Un-opened means the protective seal on the bottle or container, or the shrink-wrap on the box or kit, has not been broken and the product has not otherwise been damaged in any way. You may use the original packaging for the return or acquire your own. We will provide the return shipping label. We DO NOT accept returns for NuMedica products once the protective product seal has been broken.

Upon receipt of returned product(s), we will refund your credit card within three business days for the product(s) returned.