Product currently not available from NuMedica—estimated date not known. Will be relisted when we have more specific information.
Topical cream that provides the nutrients essential for optimal neurological and immune system function.*
Reviews are from verified customers who purchased the product on SupplementRelief.com. They are intended to describe the quality and usefulness of the specific product i.e. "how is the product working for you?". Any benefits or results expressed are based on individual experiences that are unique, cannot be guaranteed, and have not been evaluated by the FDA. Consult with your healthcare practitioner to determine if any supplement you are considering purchasing would be a good option for your specific needs.
I've been taking it. It lasts a long time. It has no adverse affects.
This product works very well I use it every morning and it gives me a boost. Helps mental focus and gives energy
I've been using this cream for some time. My functional medicine doctor recommends I continue to use it since I have methylation issues. It's pricey but a little goes a long ways.
I can tell when I've been off this cream for too long. Pain/tingling in my feet, muscle aches in my legs, periodic heart rhythm irregularities. The feet and leg issues go away and the heart rhythm issues become rare after 4-5 days back on the cream.
Our young adult son has impaired B12 pathway and has been using this supplement for several years. We notice stronger cognitive performance when he regularly applies it, and weaker cognition when he doesn't.
Felt the calming effect immediately.
NuMedica NeuroMethylation Cream is available as a topical cream to provide you with the essential nutrients that support the body's methylation processes. Methylation is among the body's most common and most important chemical processes. It occurs in essential chemical reactions such as folate metabolism and cardiovascular health, detoxification and hormonal regulation. While a healthy lifestyle can promote adequate methylation, common exposure to environmental pollutants, stress and toxins prevent most people from having enough methyl groups. NuMedica NeuroMethylation Cream supports immune health and normal neurotransmitter production and metabolism.
NuMedica NeuroMethylation Cream is formulated with five essential nutrients that support the body's methylation processes, including the "L" form of 5-MTHF, Vitamin B-12 as hydroxycobalamin, Vitamin B-12 as methylcobalamin, Vitamin B-6 and Vitamin D-3. This advanced formula, which is the foundation formula in NuMedica's Advanced Neuro-Immune Program, supports immune health and normal neurotransmitter production and metabolism. Insufficient methyl groups are associated with symptoms such as obesity, depression, mood disorders, tinnitus, chronic fatigue and more. NuMedica NeuroMethylation Cream ensures that the body's methylation processes have the support necessary for optimal function.
NuMedica NeuroMethylation Cream promotes and improves the methylation processes that are needed to increase Vitamin D levels and provide optimal B-12, B-6 and vitamin delivery to the body's nervous and immune systems. It contains 5-MTHF, which is the metabolically active form of folic acid. Nearly a third of the population is deficient in the enzymes necessary to digest the folic acid found in foods and convert it to 5-MTHF. NuMedica NeuroMethylation Cream provides the 5-MTHF necessary for optimal health. This potent cream also helps improve mood stability, cognitive function, hormonal regulation, sleep/wake cycles and immune function. It includes nutrients such as Vitamin B-12 in methylated form and Vitamin D-3 to enhance the body's neurological and physical performance.
Because this enhanced formula is applied directly to the skin, it effectively bypasses any mal-absorption issues that may occur in the gastrointestinal tract. These occurrences are especially prevalent when the body has high levels of toxins or digestive problems.
NuMedica NeuroMethylation Cream provides the nutrients necessary to combat the issues commonly associated with insufficient methyl groups.
Maintenance Dosage: 2 pumps daily; 1 pump in the morning and 1 pump in the evening.
Advanced Dosage: 3 pumps daily; 1 pump in the morning, 1 pump mid-afternoon, 1 pump in the evening.
For children under the age of 3 please consult with your healthcare practitioner.
|% Daily ValueDV 1
5-MTHF (5-methyltetrahydrofolate), hydroxocobalamin, methylcobalamin, pyridoxal-5'-phosphate, natural vitamin D3
5-MTHF plays an essential role in methylation, it enables the conversion of homocysteine to methionine, the production of serotonin and melatonin, and it is indirectly involved in the synthesis of DNA.
|1 The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advise.
We encourage you to take advantage of these related Wellness Resources on our website.
Many people suffer from Neuro-Endocrine-Immune diseases and disorders. This is a very deep and very specific group of issues, and this article will only scratch the surface of what these products can do. I encourage you to dig deeper into product descriptions if something piques your interest.
Since 2010 SupplementRelief.com has provided professional-grade supplements supported by practical wellness content focussed on healthy living, risk reduction, and chronic disease elimination.
SupplementRelief.com promotes a lifestyle ofwith emphasis on whole-foods nutrition, reasonable exercise, stress management, proper sleep, and the use of targeted, high-quality supplements to augment what is missing in our diet. We encourage others to live better through making small, gradual, healthy changes to lifestyle behaviors.
Jay is a founder of SupplementRelief.com and has provided customer service, managed and operated the business ever since.
Ask questions. Share your thoughts. Note that we cannot answer questions relating to specific medical conditions - please refer those to your qualified healthcare provider.
Post a new Comment or Reply to an existing one. Help for using the Discussion Forum.
Comments are displayed in order of the last one posted so the most recent one is at the top and the oldest one at the bottom.
Replies within a Comment are displayed in reverse order with the oldest one at the top and the most recent one at the bottom.
Each post identifies who made the post and the date and time the post was made.
Mouse over the icons for tooltips that explain what they mean.
If you see this icon you can attach an Audio file to your post.
If you see this icon you can attach a Document file to your post.
If you see this icon you can attach an Image file to your post.
If you see this icon you can attach a Video file to your post.
You will see the Ban icon (Report Post as SPAM) immediately following the Timestamp of the post. Click this icon if you feel strongly that the content posted is not appropriate and should be reviewed by the Forum Moderator. You will be provided with a confirmation dialog to be sure you wish to submit this post for review. If submitted, the Forum Moderator will be notified to review the post and will determine what type of action to take.
Click in the upper right corner of this Help modal or anywhere on the web page outside of the modal to exit Help.
* Disclaimer: This page is available exclusively for SupplementRelief.com clients. None of the information on this website is intended to replace your relationship with your healthcare provider(s). Nothing should be considered medical advice. The information, knowledge, and experience shared on this website are the opinions of SupplementRelief.com. This site and its content are intended to enhance your knowledge base as YOU MAKE YOUR OWN HEALTHCARE DECISIONS in partnership with your qualified health professional.
* These statements have not been evaluated by the Food and Drug Administration. These products and services are not intended to diagnose, treat, cure, or prevent any disease.
* There is NO GUARANTEE OF SPECIFIC RESULTS for the products or services offered, and the RESULTS CAN VARY for each individual. Any results claimed by our customers are based on individual experiences that are unique and cannot be guaranteed.
FirstFitness Nutrition and NuMedica may be promoted and sold on the internet ONLY by Authorized Resellers who have been approved by, and have registered their website domain with these companies. They strictly prohibit, and actively monitor, the UNAUTHORIZED SALE or RESALE of their products in ALL online public shopping portals including Amazon, eBay, and others and into other countries. All products purchased in SupplementRelief.com are for PERSONAL USE ONLY and CANNOT BE RESOLD to others. Please report violations of Reseller Policy directly to FirstFitness Nutrition at 800.621.4348 and to NuMedica at 800.869.8100.
The content and photographs on this website are copyrighted or Licensed Material and may not be downloaded for other than personal use. Republication, retransmission, reproduction, or any other use of the content or photographs is prohibited. ©2010-2024 SupplementRelief.com.
Are you sure you want to remove this item?
Please email if you have questions or need assistance.
We accept Visa, MasterCard, Discover and American Express credit cards.
We DO NOT retain or store your credit card information after the purchase. We DO NOT share your information with anyone. We DO NOT auto-subscribe you to anything. Your information is YOURS.
The charge will appear on your credit card statement as SupplementRelief.com with our phone number (888) 424-0032.
A safe and accurate address for delivery must be provided at the time the order is placed. Once an order has shipped, SupplementRelief.com is NOT responsible for lost or stolen packages CONFIRMED BY THE CARRIER to be delivered to the address provided for the order.
Since COVID-19, and the ensuing economic challenges in the USA economy, we respectfully ask that you allow some additional time for delivery for the carriers (USPS, UPS, and FedEx). Most orders still arrive on time, or near on time, but some may run late. We make every effort to get your order packed and into the carriers hands the same day, or by the next business morning if your order came in later in the previous day after carrier pickup, but we have no control over any delays that may happen within the shipping carrier's delivery system. Please order earlier for the time being if you are time-sensitive.
Orders that contain only FirstFitness Nutrition products have a shipping fee automatically calculated based upon the actual shipping weight of the items purchased. The charge ranges from $4.95 to $14.95.
For orders with NuMedica products you may choose from the shipping options below on the Order Checkout form in the Shipping Information section on the first line that says Choose Shipping Method.
|*International shipping costs may be higher depending upon package weight and destination. We will contact you for your approval of the additional amount if this occurs.
SupplementRelief.com may use the email or phone number provided on your Order to call or text you regarding Order Status or to inform you of changes to the Order Policy.
When your order ships we will send you a confirmation email with the delivery tracking information.
Shipping anything these days internationally is expensive. COVID resulted in more rigorous customs import processes, and now with much higher energy prices, international shipping rates are higher.
FedEx is the most reliable and faster carrier, at least for now, but they are expensive. Our FedEx international shipping fee is a minimum of $79.95. It usually makes more sense to get several months of supply (3 months or more) in one order to minimize the shipping expense per order over time. While the added weight of additional items may increase the base shipping price by a little (usually 10-25% depending upon total weight and destination), it is usually not by very much relative to shipping an additional small order later.
We also offer a lower-cost international shipping option using GlobalPost International for $39.95. So far, they have been reliable in getting packages correctly delivered but it takes 2 - 4 times as long to get the package delivered. Packages may take longer to process in the receiving country's customs process and status updates may not be reported as quickly. Please be patient if you choose this option to save money.
Some International orders may cost more to ship depending upon weight and location. If that happens we will contact you first and get your approval for any additional charge before proceeding. International orders may also be subject to additional customs fees and duties/taxes based upon the destination country's customs import laws and policies. These fees are NOT known or included on our order form and are typically charged and collected by the shipping carrier when they are delivering the product to it's final destination once the package has cleared the destination country's customs process. It is recommended that the buyer research custom import fees for the products/services they are importing beforehand to be aware of potential, additional fees.
Our manufacturers formulate their probiotics to ensure their products retain viability until they reach the consumer. Probiotics that are recommended to be refrigerated remain so until the time of shipment, then shipped alongside an ice pack to ensure potency (Note: Ice pack will not arrive frozen, and product may not arrive cold). Orders placed on a Thursday-Sunday requiring cold shipping will not ship until the following Monday.
If your order has not been shipped yet, you can request a cancellation. Your original purchase amount will be refunded within three business days. If your order has already shipped, see Returns and Refunds.
If you want to make a change to your order, please email us as soon as possible so we can make the change before your order ships. If your order has already shipped you may incur additional shipping charges for the second shipment and the return label for any products returned.
If we have made a mistake on your order, or the product arrives in a damaged or unusable condition, we will make every reasonable effort to right the situation quickly to your satisfaction. Problems of this nature must be reported to us within 5 business days of the package delivery date documented by the carrier status.
We accept returns subject to when the return is requested and the condition the product is returned in. All returns must first be authorized by contacting us. In your request, please let us know why you are returning the item(s). We will respond promptly with authorization, the return address, and a return shipping label if appropriate.
If your order has already shipped you can return any un-opened products within 30 days of receiving your order for a 100% refund of the price paid for the product, less the actual shipping charges we incurred to get the product to you originally and then returned, less a $10 restocking fee. Un-opened means the protective seal on the bottle or container, or the shrink-wrap on the box or kit, has not been broken and the product has not otherwise been damaged in any way. You may use the original packaging for the return or acquire your own. We will provide the return shipping label. We DO NOT accept returns for NuMedica products once the protective product seal has been broken.
Upon receipt of returned product(s), we will refund your credit card within three business days for the product(s) returned.