Nanomaterial Technology Aids Supplement Absorption

    2020-03-2003/20/20   
Supplements  Technology  

Nutrient absorption begins with digestion in the stomach. Our overall health is dependent upon the health of our immune system which resides primarily in our gut. Scientists are finding new ways to deliver the nutrients within a supplement to the targeted area of the body more efficiently. Nanotechnology appears to be a promising method to help you get the most out of your supplements, and possibly foods, which may help to improve your health.

Nanotechnology is already being used in various degrees for delivering bioactive materials in the pharmaceutical, foods, skin care, dietary supplements, and other industries. When matter is manipulated at this microscopic level to create new materials and products, they may exhibit new characteristics including altered solubility properties which may help increase the bioavailability of key ingredients in supplements.1

NANO = VERY small - 1 nanometer = 1/100,000th of a millimeter
Nano technology is showing promise for increasing the bioavailability of ingredients dietary supplements.

The Problem of the Standard American Diet

So why do most of us need supplements? Nature intended for us to receive nutrients from our diets, ideally from whole, natural foods with naturally occurring vitamins, minerals, and antioxidants working together to give our body the necessary nutrition it requires for optimal health and longevity. However, the typical American diet significantly lacks in whole, natural food sources, and today's processed foods have little, if any, nutritional value. In fact, medical research suggest processed foods are a significant reason for the increase of chronic disease in our society.2

The Immune System and Your Health

Our body's natural defense systems are dependent on our immune system. Given the current COVID-19 virus outbreak, it might be helpful for us to learn more about practical ways to get and stay healthy. Did you know 80% of our immune system lives in our gut? The immune system can be improved or worsened by a large variety of factors, including diet, exercise, sleep, and stress mitigation. Two effective ways to improve your immune system health are to enhance your diet with whole, natural foods and use high-quality, targeted supplements.

Consumer- vs. Professional-Grade Supplements

There are substantial differences in the quality and cost of consumer-grade versus professional-grade supplements in terms of ingredients used, absence of fillers and other harmful substances used in cheaper supplements, manufacturing process controls, quality assurance inspections, and other factors. Higher-quality supplement brands are looking for better ways to deliver the ingredients of the supplement more efficiently to the targeted area of the body the supplement is intended for. Typically, a large portion of the ingredients in supplements that are swallowed via capsule, soft gel, or even liquid form, is lost in the digestive process in the gut before ever making it to the intended target.

Nutrient Absorption Matters

Nutrient absorption begins with digestion in the stomach. After food is chewed, enzymes in our saliva break it down as it travels to the stomach. There, all the nutrients, including carbohydrates, proteins, fats, water, vitamins, and minerals pass through the small intestine and enter the bloodstream. However, the small intestine has a protective layer that selectively chooses what can and cannot enter the bloodstream. Through two processes called active and passive transport, nutrients can pass through this barrier. Passive transport allows the nutrient molecules to be easily absorbed through the barrier, expending no energy, whereas active transport requires the assistance of a helper or carrier molecule and some energy to pass the intestinal wall barrier, similar to a key unlocking a door to get someone into a room. However, not all the nutrients consumed will make it to and past this point.3

Edible Supplements (Nanocarriers) to the Rescue?

To enhance the nutritional profile of what we eat, edible products with nutrient bioactive components can very helpful, as they can replace nutrients lost in the body's natural processing or from general insufficient nutrient intake through diet. Nanocarriers can carry nutrients through the body, which are released after consumption within a target organ that needs nutritional property. These dietary supplements are similar to medicines -- you can get them in a pharmacy, prescription or over the counter -- however, these supplements are actually a unique category of food, containing active ingredients like vitamins, minerals, amino acids (which build proteins), essential fatty acids, etc. They may be more effective because they help deliver the necessary nutrients that could not be adequately received by the body from diet alone. Edible dietary supplements using nanotechnology can be manufactured in pills, capsules, tablets, and liquids.

Nanomaterial Applications

NANO technology is making its way into the premium-quality supplement industry. Some supplement manufacturers are beginning to incorporate it into their product lines. Nanomaterials are chemical substances used at a very small scale and are developed to demonstrate new characteristics as opposed to the same material at a macro-scale, demonstrating qualities like increased strength, chemical reactivity, or conductivity. The modification of properties using nanotechnology helps increase the availability of active substances like nutritional supplements, which also decreases dose-dependent toxicity and various other side-effects. However, most importantly, many formulations lend themselves to protecting these substances from degradation, allowing more of the consumed nutrient to be delivered. This is called bioavailability. Enhancing bioavailability is the product of improved solubility of bio intestinal compounds through gastrointestinal conditions, protecting them from the degrading chemical reactions and controlling their release in the GI tract and absorption through the intestinal wall due to the size of the particles, their surface properties, and physical states of the nanomaterials.4

Other Efficient Supplement Delivery Methods

While high-quality supplements have been used by healthcare practitioners to address the nutrient deficit created by our poor diets for some time, with advents in technology, we've seen other innovative supplement delivery methods in addition to nanotechnology. Liposomal and micellization techniques have come on the scene in recent years which have increased the delivery efficiency and bioavailability for certain supplements when the process is performed and managed correctly.

Liposomal Method

Liposome-delivered supplements have the potential to significantly increase the concentration of nutrients that are actually delivered and received by the body. Liposomal delivery means that a drug or supplement's preparation includes an active drug inserted inside a very small, fat-like particle. Because this form is simpler for the body to absorb, more of the drug can reach the target area of the body, and these drugs and supplements may cause fewer side-effects and work more effectively than previous delivery techniques.5

Micellization Method

Micellization includes micelles, which are effective because they allow a water-insoluble substance, like lipids, drugs, or some supplements, to be kept in a solution by insertion into the micelle core. This protects the contents as it travels through the body's digestive tract, and once the shell of the supplement is worn down sufficiently by the body's processes, forces act upon the carrier causing the surface molecules start to diminish and the micelles disperse, causing the interior contents to come out of the water-insoluble solution into the body. Some of the pharmaceutical applications of micelles include the protection of drug molecules from the body's natural degradation via hydrolysis or other physicochemical reactions, which increases the supplement's longevity and stability.6

The Take Away

Supplements can vary widely in terms of quality of ingredients, manufacturing processes and controls, and delivery techniques. High-quality supplements can be extremely useful in strengthening your immune system and helping your body's natural defense systems. Through an array of new supplement technologies, nutrients are now able to be more efficiently absorbed in higher concentrations. Nanomaterial applications allow nutrients to travel more efficiently through the body and not get broken down along the way. This increase in bioavailability gestures toward a successful future for nanomaterials and stronger immune systems around the world.

Citations:
1 https://www.nowfoods.com/now/nowledge/nanotechnology-nutritional-supplements-scientific-and-regulatory-review-and-update
2 https://www.medicalnewstoday.com/articles/325330
3 https://supplementrelief.com/liposomes-the-trojan-horse-for-making-supplements-more-effective/
4 https://www.safenano.org/knowledgebase/resources/faqs/what-is-a-nanomaterial/
5 https://www.cancer.gov/publications/dictionaries/cancer-terms/def/liposomal
6 https://www.pharmaceutical-journal.com/news-and-analysis/why-you-still-need-to-know-about-micelles/11107034.article?firstPass=false

Author

Bailey Todtenbier is a university neuroscience student and Content Developer for SupplementRelief.com. She has been writing for SupplementRelief.com as a part of the team since January 2020 and writes articles and blog posts on wellness, healthy lifestyles, and supplement technology.

Learn more about Bailey Todtenbier.

  Related Wellness Resources

We encourage you to take advantage of these FREE Wellness Resources on our website.


How to Shop and What to Eat

We are what we eat. Studies from reputable health organizations suggest that 40-60% of Americans are living with one or more chronic diseases, which negatively impacts their quality of life, reduces employment productivity, and drives up health care costs.1 Lifestyle choices, in particular, the foods we choose to put into our bodies, are making us sick. However, we do have choices regarding our nutrition.

Learn practical tips for healthy and affordable grocery shopping and consider using a list similar to the recommended natural, whole foods grocery shopping list provided to get you off to a good start!


large wooden Trojan Horse

Liposomes - A Trojan Horse for Supplement Effectivity?

Many factors are involved in how efficiently a supplement gets absorbed into the body where it is intended to go. Scientific research has shown that many tablet, capsule and liquid vitamins and supplements have an average bio-availability and absorption rate of only 5-20%. Liposomes are purported to increase the bioavailability and absorption rate by up to 80% in some cases.

Learn more about NuMedica's new line of advanced liposomal professional-grade supplements.


quality level dial from low to high

The Importance of Investing in Professional-Grade Supplements

Many consumers believe that supplements and vitamins fall into a single category of efficiency. After all, if you go to the local store and look at two bottles of the same supplement they probably have the same ingredients listed on them. What more could be involved?


Drawing of Boy In Bubble Protected by Immune System

Why You Should Care About Gut Health

The Gut (think intestinal/digestive tract) is where approximately 80% of your immune system lives. It's been overlooked in the general healthcare world, and here's why you should care about and for it.

  Supplement Recommendations

Learn more about these NuMedica Supplements on our website.


NuMedica Immune Support Program - professional dietary supplements

NuMedica Immune Support Program

Daily supplement regiment for immune system support includes Immuno PRP Spray, ImmunoMed 3-6, Liposomal Vitamin C, Micellized D3 1200, and Program Guide.


NuMedica Liposomal CoQ10 + PPQ - 6 oz professional-grade supplement

NuMedica Liposomal CoQ10 + PQQ

Provides 100 mg of CoQ10 (Ubiquinone) and 5 mg of PQQ delivered in phosphatidylcholine liposomes.


NuMedica Liposomal Curcumin - 180 ml professional-grade supplement

NuMedica Liposomal Curcumin

Provides 250 mg of curcuminoids delivered in phosphatidylcholine liposomes for optimal absorption and bioavailability.


NuMedica Liposomal Glutathione - 120 ml

NuMedica Liposomal Glutathione

Supports prime absorption and bioavailability by delivering nutrients in phosphatidylcholine liposomes.


NuMedica LIposomal Hydroxy B12 - 30 Servings professional-grade supplement

NuMedica Liposomal Hydroxy B12

Provides 1,0000 mcg of vitamin B12 in a slow-release, long-acting form that may help your body maintain more steady levels of B12.


NuMedica Liposomal Tranquinox - 30 servings professional-grade supplement

NuMedica Liposomal Tranquinox

Provides a powerful blend of GABA, Melatonin and Glutathione to help promote restful sleep and support normal circadian rhythms.


NuMedica Liposomal Vitamin C - 150 ml professional-grade supplement

NuMedica Liposomal Vitamin C

Provides 1,000 mg of Vitamin C delivered in phosphatidylcholine liposomes for optimal absorption.


NuMedica Micellized D3 + K2 - 1 fl oz professional-grade supplement

NuMedica Micellized D3 + K2 - 1 fl oz

Supports bone health and immune system function while promoting nutrient absorption with added Vitamin K2.


NuMedica Micellized D3 1200 IU - 1 fl oz professional-grade supplement

NuMedica Micellized D3 1200 IU - 1 fl oz

Supports bone health and immune system function while promoting nutrient absorption.

  • Blog Post

    Nanotechnology is already being used in various degrees for delivering bioactive materials in the pharmaceutical, foods, skin care, dietary supplements, and other industries. When matter is manipulated at this microscopic level to create new materials and products, they may exhibit new characteristics including altered solubility properties which may help increase the bioavailability of key ingredients in supplements.1

    NANO = VERY small - 1 nanometer = 1/100,000th of a millimeter
    Nano technology is showing promise for increasing the bioavailability of ingredients dietary supplements.

    The Problem of the Standard American Diet

    So why do most of us need supplements? Nature intended for us to receive nutrients from our diets, ideally from whole, natural foods with naturally occurring vitamins, minerals, and antioxidants working together to give our body the necessary nutrition it requires for optimal health and longevity. However, the typical American diet significantly lacks in whole, natural food sources, and today's processed foods have little, if any, nutritional value. In fact, medical research suggest processed foods are a significant reason for the increase of chronic disease in our society.2

    The Immune System and Your Health

    Our body's natural defense systems are dependent on our immune system. Given the current COVID-19 virus outbreak, it might be helpful for us to learn more about practical ways to get and stay healthy. Did you know 80% of our immune system lives in our gut? The immune system can be improved or worsened by a large variety of factors, including diet, exercise, sleep, and stress mitigation. Two effective ways to improve your immune system health are to enhance your diet with whole, natural foods and use high-quality, targeted supplements.

    Consumer- vs. Professional-Grade Supplements

    There are substantial differences in the quality and cost of consumer-grade versus professional-grade supplements in terms of ingredients used, absence of fillers and other harmful substances used in cheaper supplements, manufacturing process controls, quality assurance inspections, and other factors. Higher-quality supplement brands are looking for better ways to deliver the ingredients of the supplement more efficiently to the targeted area of the body the supplement is intended for. Typically, a large portion of the ingredients in supplements that are swallowed via capsule, soft gel, or even liquid form, is lost in the digestive process in the gut before ever making it to the intended target.

    Nutrient Absorption Matters

    Nutrient absorption begins with digestion in the stomach. After food is chewed, enzymes in our saliva break it down as it travels to the stomach. There, all the nutrients, including carbohydrates, proteins, fats, water, vitamins, and minerals pass through the small intestine and enter the bloodstream. However, the small intestine has a protective layer that selectively chooses what can and cannot enter the bloodstream. Through two processes called active and passive transport, nutrients can pass through this barrier. Passive transport allows the nutrient molecules to be easily absorbed through the barrier, expending no energy, whereas active transport requires the assistance of a helper or carrier molecule and some energy to pass the intestinal wall barrier, similar to a key unlocking a door to get someone into a room. However, not all the nutrients consumed will make it to and past this point.3

    Edible Supplements (Nanocarriers) to the Rescue?

    To enhance the nutritional profile of what we eat, edible products with nutrient bioactive components can very helpful, as they can replace nutrients lost in the body's natural processing or from general insufficient nutrient intake through diet. Nanocarriers can carry nutrients through the body, which are released after consumption within a target organ that needs nutritional property. These dietary supplements are similar to medicines -- you can get them in a pharmacy, prescription or over the counter -- however, these supplements are actually a unique category of food, containing active ingredients like vitamins, minerals, amino acids (which build proteins), essential fatty acids, etc. They may be more effective because they help deliver the necessary nutrients that could not be adequately received by the body from diet alone. Edible dietary supplements using nanotechnology can be manufactured in pills, capsules, tablets, and liquids.

    Nanomaterial Applications

    NANO technology is making its way into the premium-quality supplement industry. Some supplement manufacturers are beginning to incorporate it into their product lines. Nanomaterials are chemical substances used at a very small scale and are developed to demonstrate new characteristics as opposed to the same material at a macro-scale, demonstrating qualities like increased strength, chemical reactivity, or conductivity. The modification of properties using nanotechnology helps increase the availability of active substances like nutritional supplements, which also decreases dose-dependent toxicity and various other side-effects. However, most importantly, many formulations lend themselves to protecting these substances from degradation, allowing more of the consumed nutrient to be delivered. This is called bioavailability. Enhancing bioavailability is the product of improved solubility of bio intestinal compounds through gastrointestinal conditions, protecting them from the degrading chemical reactions and controlling their release in the GI tract and absorption through the intestinal wall due to the size of the particles, their surface properties, and physical states of the nanomaterials.4

    Other Efficient Supplement Delivery Methods

    While high-quality supplements have been used by healthcare practitioners to address the nutrient deficit created by our poor diets for some time, with advents in technology, we've seen other innovative supplement delivery methods in addition to nanotechnology. Liposomal and micellization techniques have come on the scene in recent years which have increased the delivery efficiency and bioavailability for certain supplements when the process is performed and managed correctly.

    Liposomal Method

    Liposome-delivered supplements have the potential to significantly increase the concentration of nutrients that are actually delivered and received by the body. Liposomal delivery means that a drug or supplement's preparation includes an active drug inserted inside a very small, fat-like particle. Because this form is simpler for the body to absorb, more of the drug can reach the target area of the body, and these drugs and supplements may cause fewer side-effects and work more effectively than previous delivery techniques.5

    Micellization Method

    Micellization includes micelles, which are effective because they allow a water-insoluble substance, like lipids, drugs, or some supplements, to be kept in a solution by insertion into the micelle core. This protects the contents as it travels through the body's digestive tract, and once the shell of the supplement is worn down sufficiently by the body's processes, forces act upon the carrier causing the surface molecules start to diminish and the micelles disperse, causing the interior contents to come out of the water-insoluble solution into the body. Some of the pharmaceutical applications of micelles include the protection of drug molecules from the body's natural degradation via hydrolysis or other physicochemical reactions, which increases the supplement's longevity and stability.6

    The Take Away

    Supplements can vary widely in terms of quality of ingredients, manufacturing processes and controls, and delivery techniques. High-quality supplements can be extremely useful in strengthening your immune system and helping your body's natural defense systems. Through an array of new supplement technologies, nutrients are now able to be more efficiently absorbed in higher concentrations. Nanomaterial applications allow nutrients to travel more efficiently through the body and not get broken down along the way. This increase in bioavailability gestures toward a successful future for nanomaterials and stronger immune systems around the world.

    Citations:
    1 https://www.nowfoods.com/now/nowledge/nanotechnology-nutritional-supplements-scientific-and-regulatory-review-and-update
    2 https://www.medicalnewstoday.com/articles/325330
    3 https://supplementrelief.com/liposomes-the-trojan-horse-for-making-supplements-more-effective/
    4 https://www.safenano.org/knowledgebase/resources/faqs/what-is-a-nanomaterial/
    5 https://www.cancer.gov/publications/dictionaries/cancer-terms/def/liposomal
    6 https://www.pharmaceutical-journal.com/news-and-analysis/why-you-still-need-to-know-about-micelles/11107034.article?firstPass=false

    Author

    Bailey Todtenbier is a university neuroscience student and Content Developer for SupplementRelief.com. She has been writing for SupplementRelief.com as a part of the team since January 2020 and writes articles and blog posts on wellness, healthy lifestyles, and supplement technology.

    Learn more about Bailey Todtenbier.

  • Articles

      Related Wellness Resources

    We encourage you to take advantage of these FREE Wellness Resources on our website.


    How to Shop and What to Eat

    We are what we eat. Studies from reputable health organizations suggest that 40-60% of Americans are living with one or more chronic diseases, which negatively impacts their quality of life, reduces employment productivity, and drives up health care costs.1 Lifestyle choices, in particular, the foods we choose to put into our bodies, are making us sick. However, we do have choices regarding our nutrition.

    Learn practical tips for healthy and affordable grocery shopping and consider using a list similar to the recommended natural, whole foods grocery shopping list provided to get you off to a good start!


    large wooden Trojan Horse

    Liposomes - A Trojan Horse for Supplement Effectivity?

    Many factors are involved in how efficiently a supplement gets absorbed into the body where it is intended to go. Scientific research has shown that many tablet, capsule and liquid vitamins and supplements have an average bio-availability and absorption rate of only 5-20%. Liposomes are purported to increase the bioavailability and absorption rate by up to 80% in some cases.

    Learn more about NuMedica's new line of advanced liposomal professional-grade supplements.


    quality level dial from low to high

    The Importance of Investing in Professional-Grade Supplements

    Many consumers believe that supplements and vitamins fall into a single category of efficiency. After all, if you go to the local store and look at two bottles of the same supplement they probably have the same ingredients listed on them. What more could be involved?


    Drawing of Boy In Bubble Protected by Immune System

    Why You Should Care About Gut Health

    The Gut (think intestinal/digestive tract) is where approximately 80% of your immune system lives. It's been overlooked in the general healthcare world, and here's why you should care about and for it.

  • Supplements

      Supplement Recommendations

    Learn more about these NuMedica Supplements on our website.


    NuMedica Immune Support Program - professional dietary supplements

    NuMedica Immune Support Program

    Daily supplement regiment for immune system support includes Immuno PRP Spray, ImmunoMed 3-6, Liposomal Vitamin C, Micellized D3 1200, and Program Guide.


    NuMedica Liposomal CoQ10 + PPQ - 6 oz professional-grade supplement

    NuMedica Liposomal CoQ10 + PQQ

    Provides 100 mg of CoQ10 (Ubiquinone) and 5 mg of PQQ delivered in phosphatidylcholine liposomes.


    NuMedica Liposomal Curcumin - 180 ml professional-grade supplement

    NuMedica Liposomal Curcumin

    Provides 250 mg of curcuminoids delivered in phosphatidylcholine liposomes for optimal absorption and bioavailability.


    NuMedica Liposomal Glutathione - 120 ml

    NuMedica Liposomal Glutathione

    Supports prime absorption and bioavailability by delivering nutrients in phosphatidylcholine liposomes.


    NuMedica LIposomal Hydroxy B12 - 30 Servings professional-grade supplement

    NuMedica Liposomal Hydroxy B12

    Provides 1,0000 mcg of vitamin B12 in a slow-release, long-acting form that may help your body maintain more steady levels of B12.


    NuMedica Liposomal Tranquinox - 30 servings professional-grade supplement

    NuMedica Liposomal Tranquinox

    Provides a powerful blend of GABA, Melatonin and Glutathione to help promote restful sleep and support normal circadian rhythms.


    NuMedica Liposomal Vitamin C - 150 ml professional-grade supplement

    NuMedica Liposomal Vitamin C

    Provides 1,000 mg of Vitamin C delivered in phosphatidylcholine liposomes for optimal absorption.


    NuMedica Micellized D3 + K2 - 1 fl oz professional-grade supplement

    NuMedica Micellized D3 + K2 - 1 fl oz

    Supports bone health and immune system function while promoting nutrient absorption with added Vitamin K2.


    NuMedica Micellized D3 1200 IU - 1 fl oz professional-grade supplement

    NuMedica Micellized D3 1200 IU - 1 fl oz

    Supports bone health and immune system function while promoting nutrient absorption.


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