Understanding Inflammation's Link to Obesity, Diabetes, & Disease
This article provides introductory knowledge on the role of blood sugar and body fat on inflammation. Inflammation is the center-point of disease and the main contributor to obesity.
Wellness, from the standpoint of the body, is reduced inflammation.
Achieving physiologic balance is key to wellness. Physiologic balance (consider this the optimal environment for the body to function) involves the individual cell's ability to build, repair, detoxify, and perform their unique metabolic function. Physiologic balance is achieved through proper food, fitness, stress reduction disciplines, and nutrients. The combination of these results in peak metabolic performance... and a body through which dreams are realized!
When we address these needs of the body, it allows the body to do what it does best: build lean body mass, reduce body fat, and ultimately drive down inflammation which is the central process of disease. Wellness, from the standpoint of the body, is reduced inflammation.
Inflammation is the central meeting point of disease. You might consider inflammation to be disease and disease to be inflammation. Wellness, on the cellular level, is REDUCED INFLAMMATION.
What drives inflammation? Sugar!
Blood sugar and blood fat regulation are central to health and are tied together. For instance, diabetics have elevated blood sugars and blood fat levels and are therefore prone to developing diseases of the blood vessels (which can lead to heart attack) and obesity (due to resistance to insulin, which causes cells to remove blood sugar from the blood stream.)
Blood sugar (glucose and fructose) is also inflammatory to the body because excess sugar will bind to proteins in the blood stream creating "advanced glycation end products", or AGEs. AGEs are known to be associated with age related diseases and diabetes-related inflammatory conditions. Inflammatory conditions include asthma, arthritis, heart attack (due to atherosclerosis or blood vessel inflammation), and neuropathy.
In fact, cooking can promote disease through the production of AGEs. Cooking is chemistry: combing two or more elements in the presence of heat! So, super-heated foods and sugars (think french fries and funnel cakes) can create AGE products by causing sugars to bind to proteins. Be aware, you can actually ingest AGE products which may be the equivalent of eating inflammation! Essentially, you might be eating inflammation.
No nutritional product, diet, or herb can replace optimal eating habits. Supplements in and of themselves are helpful for providing missing nutrition but they are not a substitute for poor diet! Unfortunately, very few people understand what healthy eating means- so we encourage to be informed and apply what you should know! We provide Wellness Educational Resources on our website that also include a Wellness Blog and a Healthy Living Whole Foods Cookbook. There are many other sources of reliable information including PubMed and your healthcare providers.
Research shows that adiponectin decreases liver production of glucose, increases the uptake of blood sugar, stimulates fat breakdown and clearance in the body, protects bloods vessels, increases insulin sensitivity, and promotes weight loss.
So let's put it all together...
- Inflammation is central to disease.
- Blood sugar is associated with inflammation.
- Excess fat tissue promotes inflammation through reduced production of the protein hormone adiponectin.
- Nutrients and the african herb X promote physiologic balance and activity of adiponectin to reduce fat.
- Reducing fat will reduce inflammation.
- Reducing fat will reduce blood sugar levels, which also reduces inflammation.
- Educating yourself on clean eating, stress reduction, and optimal gastrointestinal health along with optimal nutritional supplementation can help you achieve wellness through balanced body systems!
- Obviously, this is a complex issue and represents the cutting edge in the science of wellness.
- Tan, K. C.; Chow; Lam; Lam; Bucala; Betteridge; Ip (2006). "Advanced glycation endproducts in nondiabetic patients with obstructive sleep apnea". Sleep 29 (3): 329-333. PMID 16553018. edit
- Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Münch G. Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease. Neurobiol Aging. 2009 May 21.
- Simm A, Wagner J, Gursinsky T, Nass N, Friedrich I, Schinzel R, Czeslik E, Silber RE, Scheubel RJ. Advanced glycation endproducts: a biomarker for age as an outcome predictor after cardiac surgery? Exp Gerontol. 2007 Jul;42(7):668-75.
- Zimmerman GA, Meistrell M 3rd, Bloom O, Cockroft KM, Bianchi M, Risucci D, Broome J, Farmer P, Cerami A, Vlassara H, et al. Neurotoxicity of advanced glycation endproducts during focal stroke and neuroprotective effects of aminoguanidine. Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3744-8.
- Shaikh S, Nicholson LF. Advanced glycation end products induce in vitro cross-linking of alpha-synuclein and accelerate the process of intracellular inclusion body formation. J Neurosci Res. 2008 Jul;86(9):2071-82.
- Fuentealba D, Friguet B, Silva E. Advanced glycation endproducts induce photocrosslinking and oxidation of bovine lens proteins through type-I mechanism. Photochem Photobiol. 2009 Jan-Feb;85(1):185-94.
- Gul A, Rahman MA, Hasnain SN. Role of fructose concentration on cataractogenesis in senile diabetic and non-diabetic patients. Graefes Arch Clin Exp Ophthalmol. 2009 Jun;247(6):809-14.
- Haus, J.; Carrithers, J.; Trappe, S.; Trappe, T. (2007). "Collagen, cross-linking, and advanced glycation end products in aging human skeletal muscle". Journal of applied physiology (Bethesda, Md. : 1985) 103 (6): 2068-2076. doi:10.1152/japplphysiol.00670.2007. PMID 17901242. edit
- Glenn, J.; Stitt, A. (2009). "The role of advanced glycation end products in retinal ageing and disease". Biochimica et Biophysica Acta 1790 (10): 1109-1116. doi:10.1016/j.bbagen.2009.04.016. PMID 19409449. edit
- Semba, R. D.; Ferrucci, L.; Sun, K.; Beck, J.; Dalal, M.; Varadhan, R.; Walston, J.; Guralnik, J. M. et al. (2009). "Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women". Aging clinical and experimental research 21 (2): 182-190. PMC 2684987. PMID 19448391. edit
- Semba, R.; Najjar, S.; Sun, K.; Lakatta, E.; Ferrucci, L. (2009). "Serum carboxymethyl-lysine, an advanced glycation end product, is associated with increased aortic pulse wave velocity in adults". American journal of hypertension 22 (1): 74-79. doi:10.1038/ajh.2008.320. PMC 2637811. PMID 19023277. edit
- Yan, S. F.; D'Agati, V.; Schmidt, A. M.; Ramasamy, R. (2007). "Receptor for Advanced Glycation Endproducts (RAGE): a formidable force in the pathogenesis of the cardiovascular complications of diabetes & aging". Current molecular medicine 7 (8): 699-710. doi:10.2174/156652407783220732. PMID 18331228. edit
- Gugliucci A, Bendayan M (1996). "Renal fate of circulating advanced glycated end products (AGE): evidence for reabsorption and catabolism of AGE-peptides by renal proximal tubular cells". Diabetologia 39 (2): 149-60. doi:10.1007/BF00403957. PMID 8635666.
- Yan HD, Li XZ, Xie JM, Li M (2007). "Effects of advanced glycation end products on renal fibrosis and oxidative stress in cultured NRK-49F cells". Chin. Med. J. 120 (9): 787-93. PMID 17531120.
- Gugliucci A, Mehlhaff K, Kinugasa E, et al. (2007). "Paraoxonase-1 concentrations in end-stage renal disease patients increase after hemodialysis: correlation with low molecular AGE adduct clearance". Clin. Chim. Acta 377 (1-2): 213-20. doi:10.1016/j.cca.2006.09.028. PMID 17118352
Dr. Jamie Wright, DO, MS, FACOOG, ABAARM has over 20 years of experience in the medical field. He graduated from Michigan State University / College of Osteopathic Medicine medical school in 2001. He is Double Board Certified with a Master's Degree in Metabolic and Nutritional Medicine.
Learn more about Jamie Wright.
We encourage you to take advantage of these FREE Wellness Resources on our website.
Brandy's Weight Loss Journey: Part 4 - Why Do Diets Fail?
Today we conclude Brandy's weight loss journey where we discuss the common pitfalls of "diets".
Diet Failure: Part 2 - Do I Look Puffy to You?
What role does inflammation play in difficulty with weight loss? This second post of a three-part blog series examines the three main reasons "dieting" fails.
Healthy Living Whole Foods Cookbook
The foods we choose to put into our body should be helping us live more vibrant and productive lives but for many are they are the leading contributor to chronic disease.
Many people know "what" to do to be healthy, but HOW do you do it? One of the best ways we have found is to show people how we eat as a family. This customizable, whole foods cookbook features healthy, affordable, great-tasting recipes that are easy-to-make.
We hope you enjoy these recipes and encourage you to share them with your family and friends!
We also encourage you to browse through the Related Content section on this page to find great articles about nutrition and healthy living.
Take some time to purge your life of clutter, bad food, and stress!
The information, knowledge, and experience shared on this website is the opinion of SupplementRelief.com. This site and its content is intended to enhance your knowledge base as YOU MAKE YOUR OWN HEALTHCARE DECISIONS in partnership with your qualified health professional. These statements have not been evaluated by the Food and Drug Administration. Any products referred to are not intended to diagnose, treat, cure or prevent any disease.
Comments are displayed in order of the last one posted so the most recent Comment is at the top and older Comments are towards the bottom. Replies within a Comment are displayed in reverse order with the oldest Reply at the top and the most recent one at the bottom.
Each post identifies who made the post and the date and time the post was made.
Mouse over the icons for tooltips that explain what the data means.
If you see this icon you can attach an Audio file to your post.
If you see this icon you can attach a Document file to your post.
If you see this icon you can attach an Image file to your post.
If you see this icon you can attach a Video file to your post.
You will see the Ban icon (Report Post as SPAM) immediately following the Timestamp of the post. Click this icon if you feel strongly that the content posted is not appropriate and should be reviewed by the Forum Moderator. You will be provided with a confirmation dialog to be sure you wish to submit this post for review. If submitted, the Forum Moderator will be notified to review the post and will determine what type of action to take.
Click in the upper right corner of this Help modal or anywhere on the web page outside of the modal to exit Help.×